A non-gene-centered view on the evolution of eukaryotes


  • Abyt Ibraimov Laboratory of Human Genetics, National Center of Cardiology and Internal Medicine, 3 Togolok Moldo str., Bishkek,720 040, Kyrgyzstan.


C-heterochromatin, Q-heterochromatin, Cell thermoregulation, non-coding DNA, Modern Synthesis, non-gene-centric evolution.


Evolution is a historical process. It is unlikely that we will ever be able to fully understand it, but still we are moving towards the truth. Below we discuss the assumptions that: a) evolution is not only an the origin of various species of animals and plants, but the major transitions in life history  on the Earth, such as  the emergence  of  mitotic chromosomes, mitosis, meiosis,  eukaryotic  cells,   biological   sex,  multicellular  organisms,  homoeothermic animals,  including humans; b) the material basis of the origin and further evolution of the eukaryotic organisms were, apparently,  non-coding DNAs (ncDNAs), while genes, though important, were of secondary importance; c) ncDNAs, due to their molecular structure (short, repeated thousands and millions times DNA sequences), behavior during the cell cycle (remain condensed through the cell), genetic organization (they do not encode polypeptide chains),  cytological  organization  (an  ability  to  dense  packing  in  the  cell),  the  localization  features (centromere and telomeric sites, as well as the regions of nucleolar organizers of chromosomes) and wide variability, were the main genetic material in the evolution of eukaryotic organisms.


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