Membrane Bioelectric Properties: a Biophysical approaches to cell physiology- A study revision

  • Sebastião David Santos-Filho Departamento de Biociências – UFRN, RN, Brasil
Keywords: Biophysics; Bioelectrogenesis; Biomembrane; Ion Channels;


The contributions of Biophysics scientists measuring aspects of the membrane electricity have been so well thought of that multiple prizes have been given out in this field. The field has generated quantitative findings based on the Goldman field equation and the Nernst equation that provide understanding into the importance of sodium and potassium in cell signaling. The graded and action potentials that bring information in the interior the cell and all over the body are central in the considerations of the brain and the activities of muscle. This work covers the biophysics essential of these process.


[1] Yang J, Hinner MJ. Getting across the cell membrane: An overview for small molecules, peptides, and proteins. Methods Mol Biol. 2015; 1266: 29-53. doi: 10.1007/978-1-4939-2271-7_3.
[2] Sugiharto S, Lewis TM, Moorhouse AJ, Schofield PR, Barry PH. Anion-Cation permeability correlates with hydrated counterion sizein glycine receptor channels. Biophys J. 2008; 95: 4698-4715.
[3] Dijkstra K, Hofmeijer J, van Gils SA, van Putten MJ. A biophysical model for cytotoxic cell swelling. J Neurosci. 2016; 36: 11881-11890.
[4] Stampert JA, Gomez E, Brothers M, Begtrup G, Heikenfeld J. Continuous quantifiable and simple osmotic preconcentration and sensing with in microfluidic devices. PLoS ONE. 2019; 14: e0210286.
[5] Dmitriev AV, Dmitriev AA, Linsenmeier RA. The logic of ionic homeostasis: Cations are for voltage but not for volume. PLoS Comput Biol. 2019; 15: e1006894.
[6] Liu J, lilly MN, Shapiro JI. Targeting Na/K-ATPase signaling: A new approach to control oxidative stress. Curr Pharm Des. 2018; 24: 359-364. doi: 10.2174/1381612824666180110101052.
[7] Danchin A, Nikel PI. Why nature chose potassium. J Mol Evol. 2019; 87: 271-288. doi: 10.10007/s00239-019-09915-2.
[8] Pivovarov AS, Calahorro F, Walker RJ. Na+/K+-pump and neurotransmitter membrane receptors. Invert Neurosci. 2019; 19: 1-16. doi: 10.1007/s10158-018-0221-7.
[9] Zablotskii V, Polyakova T, Lunov O, Dejneka A. How a high-gradient magnetic field could affect cell life. Sci Rep. 2016; 6: 37407. doi: 10.1038/srep37407.
[10] Schwiening CJ. Brief historical perspective: Hodgkin and Huxley. J Physiol. 2012; 11: 2571-2575.
[11] Alvarez O, Latorre R. The enduring legacy of the “constant-field equation” in membrane ion transport. J Gen Physiol. 2017; 149: 911-920. doi: 10.1085/jgp.201711839.
[12] Fertig N, Blick RH, Behrends JC. Whole cell patch clamp recording performed on a planar glass chip. Biophys J. 2002: 82: 3056-3062.
[13] Smithers HE, Terry JR, Brown JT, Randall AD. Aging-associated changes to intrinsic neuronal excitability in the bed nucleus of the stria terminalis is cell type-dependent. Front Aging Neurosci. 2017; 9: 424. doi: 103389/fnagi.2017.00424.
[14] Kole MHP, Hallermann S, Stuart GJ. Single Ih channels in pyramidal neuron dendrites: Properties, distribution, and impact on action potential output. J Neurosci.2006; 26: 1677-1687. doi: 10.1523/JNEUROSCI. 3664-05.2006.
[15] Shah SI, Demuro A, Mak DD, Parker I, Pearson JE, Ullah G. Trace specks: A software for automated idealization of noisy patch-clamp and imaging data. Biophys J. 2018; 115: 9-21.
[16] Astaburuaga R, Haro O, Stauber T, Relogio A. A mathematical model of lysosomal ion homeostasis points to differential effects of Cl-transport in Ca2+ dynamics. Cells. 2019; 8: 1263. doi: 10.3390/cells8101263.
[17] Wang J, Zhang L, Xue J, Hu G. Ion diffusion coefficient measurements in nanochannels at various concentrations. Biomicrofluidics. 2014; 8: 024118. doi:10.1053/1.4874215.
[18] kadir LA, Stacey M, Barrett-Jolley R. Emerging roles of the membrane potential: Action beyond the action potential. Front Physiol. 2018; 9: 1661. doi: 10.3389/fphys.2018.01661.
[19] Yang J, Wang B, You Y, Chang Wj, Tang K, Wang YC, Zhang W, Ding F, Gunasekaran S. Probing the modulated formation of gold nanoparticle-beta lactoglobulin corona complexes and its applications. Nanoscale. 2017; 9: 17757-17769. doi: 10.1039/c7nr02999c.
[20] Kozlowski R, Ragupathi A, Dyer RB. Characterizing the surface coverage of protein-gold nanoparticle bioconjugates. Bioconjug Chem. 2018; 29: 2691-2700. doi: 10.1021/acs.biconjchem.8b00366.
[21] Wang Y, van Asdonk K, Zijlstra P. A robust and general approach to quantitatively conjugate enzymes to plasmonic nanoparticles. Langmuir. 2019; 35: 1335613363. doi: 10.0121/acs.langmuir.9b01879.
[22] Lee SH, Jun BH. Silver nanoparticles: Synthesis and application for nanomedicine. Int J Mol Sci. 2019; 20: 865. doi: 10.3390/ijms20040865.
[23] Kay AR, Blaustein MP. Evolution of our understandint of cell volume regulation by pump-leak mechanism. J Gen Physiol. 2019; 151: 407-416. doi: 10.1085/jpg.201812274.
[24] Grimm C, Vierock J, Hegemann P, Wietek J. Whole-cell patch-clamp recordings for electrophysiological determination of ion selectivity in channel rhodopsins. J Vis Exp. 2017; 123: 55497. doi: 10.2791/55497.
[25] Bau R, Gao G, Xing Y, Xue H. Two outward potassium current types are expressed during the neural differentiation of neural stem cells. Neural Regen Res. 2013; 8: 2656-2665. doi: 20.3969/j.issn.1673-5374.2013.28.008.
Review Article